Induction of CD4+ CD25+ Foxp3+ T regulatory cells by dendritic cells derived from ILT3 lentivirus-transduced human CD34+ cells
G Ge, P Tian, H Liu, J Zheng, X Fan, C Ding, Z Jin… - Transplant …, 2012 - Elsevier
Immunoglobulin-like transcript 3 (ILT3) belongs to a family of inhibitory receptors with
cytoplasmic immunoreceptor tyrosine based inhibitory motifs (ITIMs). Numerous studies
have reported that increased ILT3 expression is associated with the tolerogenic properties of
antigen-presenting cells (APCs) including dendritic cells (DCs). In this study, human CD34+
hematopoietic stem/progenitor cells (HPSCs) were transduced with self-inactivating lentiviral
vector carrying the ILT3 gene, and then induced to differentiate into DCs. Long-term and …
cytoplasmic immunoreceptor tyrosine based inhibitory motifs (ITIMs). Numerous studies
have reported that increased ILT3 expression is associated with the tolerogenic properties of
antigen-presenting cells (APCs) including dendritic cells (DCs). In this study, human CD34+
hematopoietic stem/progenitor cells (HPSCs) were transduced with self-inactivating lentiviral
vector carrying the ILT3 gene, and then induced to differentiate into DCs. Long-term and …
