Skeletal muscle atrophy is a serious and highly prevalent condition that remains poorly
understood at the molecular level. Previous work found that skeletal muscle atrophy involves
an increase in skeletal muscle Gadd45a expression, which is necessary and sufficient for
skeletal muscle fiber atrophy. However, the direct mechanism by which Gadd45a promotes
skeletal muscle atrophy was unknown. To address this question, we biochemically isolated
skeletal muscle proteins that associate with Gadd45a as it induces atrophy in mouse …